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Imipramine
Description A tricyclic antidepressant. Its plasma concentrations vary significantly between subjects. 
Therapeutic Low 0.0100
Therapeutic High 0.1100
Units ug/mL 
Specimen P 
Half Life Low 8.00
Half Life High 20.00
VOD Low 20.00
VOD High 40.00
Toxic Level 0.500
Lethal Level 2.000
Plasma to Whole Blood ratio 0.98
Warnings Imipramine toxicity is manifested by hyperactivity, seizures, respiratory depression, hypertension, cardiac arrhythmia, hyperpyrexia, tachycardia, urinary retention, coma, circulatory collapse, and death. This antidepressant has a potential for enterohepatic recycling, thereby compounding its toxicity. Warnings - may impair mental and/or physical ability required for the performance of potentially hazardous tasks (e.g., driving, operating heavy machinery).