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Codeine

Description Codeine is an opiate agonist used by itself or in combination with acetaminophen or similar products for the management of mild pain. It is also used as a cough suppressant and an antidiarrheal agent. Plasma protein binding is 7 to 25%. 
Therapeutic Low 0.1000
Therapeutic High 0.2300
Units ug/mL 
Specimen
Half Life Low 2.00
Half Life High 4.00
VOD Low 3.50
VOD High 0.00
Toxic Level 0.500
Lethal Level 0.000
Plasma to Whole Blood ratio 0.00
Warnings While deaths attributed directly to codeine are rare, deaths are prevalent when used in combination with alcohol and/or other drugs. Codeine may be habit-forming and may impair mental and/or physical abilities to perform potentially hazardous tasks such as driving, flying, etc. Warnings - may impair mental and/or physical ability required for the performance of potentially hazardous tasks (e.g., driving, operating heavy machinery).